The world has been grappling with the COVID-19 pandemic for almost two years now, and the question on everyone's mind remains: When will it end? Many have drawn parallels between the Spanish Flu and the SARS-CoV-2 virus, noting the Spanish Flu's four waves over two years from 1918 to 1920. Here we are, nearly two years into the COVID-19 pandemic, and we've seen four waves ourselves. Could this mean an end is insight for 2022? Let's delve into the expert opinions, past virus trajectories, and the latest research to make sense of it all.